Free Download Molecular Biology in Medicinal Chemistry
This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods.
With its examination of these novel methods and generous practical advice, this is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action. To download this book click download button  |
Showing posts with label MOLECULARBIOLOGY. Show all posts
Showing posts with label MOLECULARBIOLOGY. Show all posts
Tuesday, 30 December 2014
Monday, 29 December 2014
Free Download Cell Biology, Genetics, Molecular Biology, Evolution and Ecology by Verma, Agarwal
Free Download Cell Biology, Genetics, Molecular Biology, Evolution and Ecology by Verma, Agarwal
The multicoloured edition of the textbook of Cell Biology, Genetics, Molecular Biology, Evolution and Ecology is the outcome of sincere and combined efforts of the authors and editors (namely Shishir Bhatnagar, Shubha Pradhan, Malini Kothiyal) and young but talented persons of DTP of S.Chand & Company Ltd. Their main motive remained to provide relevant coloured photographs explaining various intricate biological
topics. Multicoloured figures and photographs of this edition would help our target readers to understand and fully appreciate the very gist of the subject matter. Authors and editors have remained quite choosy and vigilant regarding relevance and authenticity of each and every illustration/picture finding its place in this textbook.
Authors earnestly hope that this multicoloured edition of the textbook of Cell Biology, Genetics, Molecular Biology, Evolution and Ecology will enhance the curiosity of our target readers to know more and more about the subject. It will arm them with latest information for facing any type of exam quite adequately.
This book is meant for students of B.Sc., B.Sc. (Hons.) and M.Sc. of biological group. Students appearing in entrance exams of C.P.M.T., I.F.S., P.C.S. and I.A.S., etc, may be immensely benefited by this book.
To download this book click on download button
topics. Multicoloured figures and photographs of this edition would help our target readers to understand and fully appreciate the very gist of the subject matter. Authors and editors have remained quite choosy and vigilant regarding relevance and authenticity of each and every illustration/picture finding its place in this textbook.
Authors earnestly hope that this multicoloured edition of the textbook of Cell Biology, Genetics, Molecular Biology, Evolution and Ecology will enhance the curiosity of our target readers to know more and more about the subject. It will arm them with latest information for facing any type of exam quite adequately.
This book is meant for students of B.Sc., B.Sc. (Hons.) and M.Sc. of biological group. Students appearing in entrance exams of C.P.M.T., I.F.S., P.C.S. and I.A.S., etc, may be immensely benefited by this book.
To download this book click on download button
Free Download Functional Genomics: Methods in Molecular Biology Volume 224
Free Download Functional Genomics: Methods in Molecular Biology Volume 224
This collection of robust, readily reproducible methods for microarray-based studies includes expert guidance in the optimal data analysis and informatics. On the methods side are proven techniques for monitoring subcellular RNA localization en masse, for mapping chromosomes at the resolution of a single gene, and for surveying the steady-state genome-wide distribution of DNA binding proteins in vivo. For those workers dealing with massive data sets, the book discusses the methodological aspects of data analysis and informatics in the design of microarray experiments, the choice of test statistic, and the assessment of observational significance, data reduction, and clustering.
To download this book click on download button  |
Free Download Methods In Molecular Biology - Pcr Protocols Volume 226
Free Download Methods In Molecular Biology - Pcr Protocols Volume 226
Drawing on the highly successful first edition, this newly-revised second edition covers the many advances made in PCR technology since the first book, which has been used in more than 10,000 laboratories worldwide. As PCR technology has advanced significantly since the first edition, and has expanded its use in the clinical laboratory of physician/researchers, the scope of this book is greatly expanded to enable researchers at all levels to easily reproduce and adapt PCR experiments to their own specific requirements. The meethods selected represent worked examples from many fields that can be reproduced and adapted for use within the reader's laboratory. The authors have provided both a primer to allow the reader to gain basic experience of different PCR techniques, as well as in-depth insight into a variety of the more complex applications of PCR. This book will be essential for the labs of all biochemists, molecular biologists, geneticists and researchers utilizing the PCR techinque in their work .
To download this book click on download button  |
Free Download Methods in Molecular Biology Volume 175 - Genomics Protocols
Free Download Methods in Molecular Biology Volume 175 - Genomics Protocols
Genomics Protocols was compiled as a comprehensive manual for whole-genome research and analysis. The topics can be put loosely into five categories: gene mapping (including discovery, identification, and localization), expression profiling, protein structure and function, gene therapy, and bioinformatics. Therefore the content is broader than genomics, covering “genomic-scale” research. The book is written for researchers in the field who want to expand their genomic analysis as well as researchers who want to enter into this world. Each section is complete with background information, detailed materials, step-by-step methods, and notes.
Different authors contributed to each of the more than 30 chapters in this book. An advantage of numerous contributors is that each chapter is written by experts who have performed the experiments successfully. Because of the multiple contributors, similar procedures are outlined in several chapters, although examining overlapping methods of different laboratories may be useful in setting up the procedure in your laboratory. Chapters also differ slightly in the detail provided.
Although this is a comprehensive book, the editors may not have achieved the goal to provide a guide for beginners in the field. The methods are detailed, but a true beginner may have difficulty with some of the terminology. An exciting potential exists to transition some of these methods into the clinical laboratory. Near-future clinical applications include single-nucleotide polymorphism (SNP) haplotyping for complex genetic diseases, expression profiling for cancers, and gene therapy. Clinicians interested in setting up these methods will need to modify the protocols to meet clinical needs.
Highlights of the book include computer programs and websites for data analysis and entrance into the world of proteomics. The comprehensive lists of materials and sources are useful, particularly when commercial sources are not available. Flowcharts and outlines of procedures are well done and supplement the protocols well. Detailed step-by-step procedures are given, although the only way to judge how complete procedures are is to try them at the bench (which admittedly I did not do). The notes at the end of each section give extra tips. Be sure to review them before attempting any of the procedures, because some notes will be essential to successful experiments. In addition, they are among the most interesting parts of the book.
To download this book click on download button
Different authors contributed to each of the more than 30 chapters in this book. An advantage of numerous contributors is that each chapter is written by experts who have performed the experiments successfully. Because of the multiple contributors, similar procedures are outlined in several chapters, although examining overlapping methods of different laboratories may be useful in setting up the procedure in your laboratory. Chapters also differ slightly in the detail provided.
Although this is a comprehensive book, the editors may not have achieved the goal to provide a guide for beginners in the field. The methods are detailed, but a true beginner may have difficulty with some of the terminology. An exciting potential exists to transition some of these methods into the clinical laboratory. Near-future clinical applications include single-nucleotide polymorphism (SNP) haplotyping for complex genetic diseases, expression profiling for cancers, and gene therapy. Clinicians interested in setting up these methods will need to modify the protocols to meet clinical needs.
Highlights of the book include computer programs and websites for data analysis and entrance into the world of proteomics. The comprehensive lists of materials and sources are useful, particularly when commercial sources are not available. Flowcharts and outlines of procedures are well done and supplement the protocols well. Detailed step-by-step procedures are given, although the only way to judge how complete procedures are is to try them at the bench (which admittedly I did not do). The notes at the end of each section give extra tips. Be sure to review them before attempting any of the procedures, because some notes will be essential to successful experiments. In addition, they are among the most interesting parts of the book.
To download this book click on download button
Free Download Methods in Molecular Biology Volume 499 - Candida Albicans Methods and Protocols
Free Download Methods in Molecular Biology Volume 499 - Candida Albicans Methods and Protocols
Over the course of the past decade, there have been remarkable advances in the study of human pathogenic fungi. These developments have taken place throughout a wide range of disciplines, and have come as the result of newly available genome sequences of pathogens such as candida albicans and other model fungi. In Candida Albicans: Methods and Protocols, expert researchers explore these exciting new insights, focusing on the study of medically important fungi and Candida spp in particular. Chapters examine critical aspects of molecular methods, providing information on reporter gene assays, transformation, gene expression in vivo, and methods for large-scale gene disruption. At the same time, the work includes in-depth descriptions of disease models of candidiasis, facts about strain identification, and guidelines on the preparation of samples for proteomic investigations and tandem affinity purification. Composed in the highly successful "Methods in Molecular BiologyTM" series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting edge, Candida Albicans: Methods and Protocols is an invaluable source of methods for investigators in the exhilarating fields of medical and molecular mycology.
To download this book click on download button
To download this book click on download button
Wednesday, 24 December 2014
Biochemistry, The Molecular Basis of Life
Biochemistry, The Molecular Basis of Life
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Biochemistry, The Molecular Basis of Life
Click here to Download, PDF (Bookza Link)
OR
Click here to Download, DJVU (Mediafire Link)
Book Description
Biochemistry: The Molecular Basis of Life is the ideal text for students who do not specialize in biochemistry but who require a strong grasp of biochemical principles. The goal of this edition has been to enrich the coverage of chemistry while better highlighting the biological context. Once concepts and problem-solving skills have been mastered, students are prepared to tackle the complexities of science, modern life, and their chosen professions.
DISTINCTIVE FEATURES
A Review of Basic Principles. To ensure that all students are sufficiently prepared for acquiring a meaningful understanding of biochemistry, the first four chapters–now streamlined for easier coverage and self-study assessment–review the principles of relevant topics such as organic functional groups, noncovalent bonding, thermodynamics, and cell structure.
Chemical and Biological Principles in Balance. Comprehensive coverage offers each instructor the flexibility to decide how much chemistry or biology he/she would like to present. Chemical mechanisms are always presented within the physiological context of the organism.
Real-World Relevance. Because students who take the survey of biochemistry course come from a range of backgrounds and have diverse career goals, the updated fifth edition consistently demonstrates the fascinating connections between biochemical principles and the fields of medicine, nutrition, agriculture, bioengineering, and forensics.
The Most Robust Problem-Solving Program Available.
* In-chapter “Worked Problems” illustrate how quantitative problems are solved and provide students with opportunities to put their knowledge into action right when new concepts are introduced.
* Dozens of “Questions” are interspersed throughout the chapters, getting students critically thinking about high-interest topics.
* Finally, hundreds of multiple-choice and short-answer questions at the end of the chapters test students’ knowledge, develop their conceptual understanding, and encourage them to apply what they have learned.
* In-chapter “Worked Problems” illustrate how quantitative problems are solved and provide students with opportunities to put their knowledge into action right when new concepts are introduced.
* Dozens of “Questions” are interspersed throughout the chapters, getting students critically thinking about high-interest topics.
* Finally, hundreds of multiple-choice and short-answer questions at the end of the chapters test students’ knowledge, develop their conceptual understanding, and encourage them to apply what they have learned.
Simple, Clear Illustrations. Biochemical concepts often require a high degree of visualization, and the McKee and McKee art program brings complex processes to life. The book includes 700+ full-color figures, many newly enhanced for a more vivid presentation in three dimensions and consistent scale and color for chemical structures.
Biochemistry, The Molecular Basis of Life
Molecular Biotechnology: Principles and Applications of Recombinant DN
Molecular Biotechnology: Principles and Applications of Recombinant DNA
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Molecular Biotechnology: Principles and Applications of Recombinant DNA
OR
OR
Book Description
Molecular biotechnology emerged as a new research field that arose as a result of the fusion in the late 1970s of recombinant DNA technology and traditional industrial microbiology. Whether one goes to the movies to see Jurassic Park with its ingenious but scientifically untenable plot of cloning dinosaurs, reads in the newspaper about the commercialization of a new “biotech” tomato that has an extended shelf life, or hears one of the critics of molecular biotechnology talking about the possibility of dire consequences from genetic engineering, there is a significant public awareness about recombinant DNA technology. In this book, we introduce and explain what molecular biotechnology actually is as a scientific discipline, how the research in the area is conducted, and how this technology may realistically impact on our lives in the future. We have written Molecular Biotechnology: Principles and Applications of Recombinant DNA to serve as a text for courses in biotechnology, recombinant DNA technology, and genetic engineering or for any course introducing both the principles and the applications of contemporary molecular biology methods. The book is based on the biotechnology course we have offered for the past 12 years to advanced undergraduate and graduate students from the biological and engineering sciences at the University of Waterloo. We have written this text for students who have an understanding of basic ideas from biochemistry, molecular genetics, and microbiology. We are aware that it is unlikely that students will have had all of these courses before taking a course on biotechnology. Thus, we have tried to develop the topics in this text by explaining their broader biological context before delving into molecular details. This text emphasizes how recombinant DNA technology can be used to create various useful products. We have, wherever possible, used experimental results and actual methodological strategies to illustrate basic concepts, and we have tried to capture the flavor and feel of how molecular biotechnology operates as a scientific venture. The examples that we have selected—from a vast and rapidly growing literature—were chosen as case studies that not only illustrate particular points but also provide the reader with a solid basis for understanding current research in specialized areas of molecular biotechnology. Nevertheless, we expect that some of our examples will be out of date by the time the book is published, because molecular biotechnology is such a rapidly changing discipline.
For the ease of the day-to-day practitioners, scientific disciplines often develop specialized terms and nomenclature. We have tried to minimize the use of technical jargon and, in many instances, have deliberately used a simple phrase to describe a phenomenon or process that might otherwise have been expressed more succinctly with technical jargon. In any field of study, synonymous terms that describe the same phenomenon exist. In molecular biotechnology, for example, recombinant DNA technology, gene cloning, and genetic engineering, in a broad sense, have the same meaning. When an important term or concept appears for the first time in this text, it is followed in parentheses with a synonym or equivalent expression. An extensive glossary can be found at the end of the book to help the reader with the terminology of molecular biotechnology.
Molecular Biotechnology: Principles and Applications of Recombinant DNA
Molecular Biology and Biotechnology By John M. Walker, Ralph Rapley
Molecular Biology and Biotechnology By John M. Walker, Ralph Rapley
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Molecular Biology and Biotechnology By John M. Walker, Ralph Rapley
Book Description
This popular textbook has been completely revised and updated to provide a comprehensive overview and to reflect all the latest developments in this rapidly expanding area. Chapters on the impact of molecular biology in the development of biotechnology have been fully updated and include the applications of molecular biology in the areas of drug design and diseases. There are also completely new chapters in developing areas such as genome technology, nanobiotechnology, regenerative medicine and biofuels. By presenting information in an easily assimilated form, this book makes an ideal undergraduate text.
From the Back Cover
One of the exciting aspects of being involved in the field of molecular biology is the ever-accelerating rate of progress, both in the development of new methodologies and the practical applications of these methodologies. This popular textbook has been completely revised and updated to provide a comprehensive overview and to reflect all the latest developments in this rapidly expanding area. Chapters on the impact of molecular biology in the development of biotechnology have been fully updated and include the applications of molecular biology in the areas of drug design and diseases. The first six chapters deal with the technology used in current molecular biology and biotechnology. These primarily deal with core nucleic acid techniques and protein expression through microbial and genetic detection methods. Further chapters address the huge advances made in gene and genome analysis and updates the rapid advances into yeast analysis, which is providing very exciting insights into molecular pathways. There are also completely new chapters in developing areas such as genome technology, nanobiotechnology, regenerative medicine and biofuels. In addition, the authors continue to ensure that biotechnology is not just considered at the gene level and full consideration continues to be given to applications and manufacturing, with chapters on downstream processing, biosensors, the applications of immobilised biocatalysts, and a new chapter on the developing area of biofuels. By presenting information in an easily assimilated form, this book makes an ideal undergraduate text. Molecular Biology and Biotechnology 5th Edition will be of particular interest to students of biology and chemistry, as well as to postgraduates and other scientific workers who need a sound introduction to this ever rapidly advancing and expanding area.
Molecular Biology and Biotechnology By John M. Walker, Ralph Rapley
Tuesday, 23 December 2014
Cell Biology, Genetics, Molecular Biology, Evolution and Ecology by Verma, Agarwal
Cell Biology, Genetics, Molecular Biology, Evolution and Ecology by Verma, Agarwal
********************************************
Cell Biology, Genetics, Molecular Biology, Evolution and Ecology by Verma, Agarwal
Click here to Download (Box Link)
OR
Click here to Download (Bookfi Link)
OR
Click here to Download (Bookfi Link)
Book Description
The multicoloured edition of the textbook of Cell Biology, Genetics, Molecular Biology, Evolution and Ecology is the outcome of sincere and combined efforts of the authors and editors (namely Shishir Bhatnagar, Shubha Pradhan, Malini Kothiyal) and young but talented persons of DTP of S.Chand & Company Ltd. Their main motive remained to provide relevant coloured photographs explaining various intricate biological
topics. Multicoloured figures and photographs of this edition would help our target readers to understand and fully appreciate the very gist of the subject matter. Authors and editors have remained quite choosy and vigilant regarding relevance and authenticity of each and every illustration/picture finding its place in this textbook.
topics. Multicoloured figures and photographs of this edition would help our target readers to understand and fully appreciate the very gist of the subject matter. Authors and editors have remained quite choosy and vigilant regarding relevance and authenticity of each and every illustration/picture finding its place in this textbook.
Authors earnestly hope that this multicoloured edition of the textbook of Cell Biology, Genetics, Molecular Biology, Evolution and Ecology will enhance the curiosity of our target readers to know more and more about the subject. It will arm them with latest information for facing any type of exam quite adequately.
This book is meant for students of B.Sc., B.Sc. (Hons.) and M.Sc. of biological group. Students appearing in entrance exams of C.P.M.T., I.F.S., P.C.S. and I.A.S., etc, may be immensely benefited by this book.
Cell Biology, Genetics, Molecular Biology, Evolution and Ecology by Verma, Agarwal
Cell Biology, Genetics, Molecular Biology, Evolution and Ecology by Verma, Agarwal
Cell Biology, Genetics, Molecular Biology, Evolution and Ecology by Verma, Agarwal
********************************************
Cell Biology, Genetics, Molecular Biology, Evolution and Ecology by Verma, Agarwal
Click here to Download (Box Link)
OR
Click here to Download (Bookfi Link)
OR
Click here to Download (Bookfi Link)
Book Description
The multicoloured edition of the textbook of Cell Biology, Genetics, Molecular Biology, Evolution and Ecology is the outcome of sincere and combined efforts of the authors and editors (namely Shishir Bhatnagar, Shubha Pradhan, Malini Kothiyal) and young but talented persons of DTP of S.Chand & Company Ltd. Their main motive remained to provide relevant coloured photographs explaining various intricate biological
topics. Multicoloured figures and photographs of this edition would help our target readers to understand and fully appreciate the very gist of the subject matter. Authors and editors have remained quite choosy and vigilant regarding relevance and authenticity of each and every illustration/picture finding its place in this textbook.
topics. Multicoloured figures and photographs of this edition would help our target readers to understand and fully appreciate the very gist of the subject matter. Authors and editors have remained quite choosy and vigilant regarding relevance and authenticity of each and every illustration/picture finding its place in this textbook.
Authors earnestly hope that this multicoloured edition of the textbook of Cell Biology, Genetics, Molecular Biology, Evolution and Ecology will enhance the curiosity of our target readers to know more and more about the subject. It will arm them with latest information for facing any type of exam quite adequately.
This book is meant for students of B.Sc., B.Sc. (Hons.) and M.Sc. of biological group. Students appearing in entrance exams of C.P.M.T., I.F.S., P.C.S. and I.A.S., etc, may be immensely benefited by this book.
Cell Biology, Genetics, Molecular Biology, Evolution and Ecology by Verma, Agarwal
Tuesday, 16 December 2014
RNA Splicing
In molecular biology and genetics, splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined. For nuclear encoded genes, splicing takes place within the nucleus after or concurrently with transcription. Splicing is needed for the typical eukaryotic messenger RNA (mRNA) before it can be used to produce a correct protein through translation. For many eukaryotic introns, splicing is done in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs), but there are also self-splicing introns.
Sanger Sequencing of DNA
Developed by Frederick Sanger and colleagues in 1977, it was the most widely used sequencing method for approximately 25 years. More recently, Sanger sequencing has been supplanted by "Next-Gen" sequencing methods, especially for large-scale, automated genome analyses. However, the Sanger method remains in wide use, primarily for smaller-scale projects and for obtaining especially long contiguous DNA sequence reads (>500 nucleotides).
Saturday, 6 December 2014
Treatment of HIV
The aim of antiretroviral treatment is to keep the amount of HIV in the body at a low level. This stops any weakening of the immune system and allows it to recover from any damage that HIV might have caused already. The drugs are often referred to as: antiretrovirals, ARVs, anti-HIV or anti-AIDS drugs.
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