The nervous system and endocrine system collaborate to increase gastric secretion and motility when food is eaten and to suppress them as the stomach empties. Gastric activity associated with eating is divided into three stages called the cephalic phase, gastric phase, and intestinal phase, based on whether the stomach is being controlled by the brain, by itself, or by the small intestine, respectively. These phases overlap and all three can occur simultaneously.
A fourth phase of acid secretion is known as the basal state which occurs in the times between meals (interdigestive phase). The level of acid secretion during these times is regulated by body weight, individual, number of parietal cells, and time of day. Acid secretion is lowest in the morning before awakening and highest at night.
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